Purpose: To observe the effects of Kuanxiongdan Capsule (ingredients: Mongolian snakegourd, tangerine peel, immature bitter
orange, Chuanxiong rhizome, leech, atractylodes rhizome, etc.) on
Serum Total Cholesterol (Tc) , triglyceride (TG),
High Density Lipoprotine (Hdl), low density lipoprotine (LDL) of rabbits with atheroscleorsis. Method: Forty healthy New Zealand big-eared white rabbits were randomly divided into 5 groups: the normal group, the modeled group, the large dosage of Kuanxiongdan Capsule group, the small dosage of Kuanxiongdan Capsule group and the Polyene Kang group. After being fed corresponding quantity of animal feed with drugs for forty days, the content of serum TC, TG, HDL, LDL were tested. Results: There was a great difference (P<0.05) between the modeled group and the normal group. The content of TC, TG, LDL was decreased obviously in both the large dosage group and the small dosage group, which was remarkably different from the modeled group (P<0.05). The content of HDL was obviously increased in the large dosage group, and in the improvement of TC,TG,LDL, the large dosage group was superior to the Polyene Kang group(P<0.05).Conclusion: Kuanxiongdan capsule can relieve the atheroscleorsis degree and prevent and treat coronary heart disease, which may relate to its function of increasing HDL and decreasing TC,TG,LDL.