OBJECTIVE To explore the effects of complex Xueshuantong dripping-pill on hemorrheology in blood stasis rats and clotting-time of mice respectively. METHODS Acute ischemic model of rats was used to carry out the hemorrheological tests and the capillary method was used to determine the clotting-time of mice. RESULTS (1)After the rats were subcutaneously injected adrenaline and treated with ice-water bath, the whole blood-viscosity under different shear stress and plasmatic viscosity were all increased. (2)After administration of compound Xueshuantong dripping-pill, the whole blood-viscosity and the whole blood reduced-viscosity were decreased under different shear stress (1 s-1,5s-1,30s-1,150s-1). (3)The maximum percentage of platelet aggregation was significantly inhibited after treatment with compound Xueshuantong dripping-pill. (4)The clotting-time of mice was elongated in all groups treated with compound Xueshuantong dripping-pill. CONCLUSION The compound Xueshuantong dripping-pill can decrease blood viscosity and inhibit platelet aggregation. Therefore, it can improve microcirculation, prevent thrombosis and protect some important organs, such as heart, brain and so on.