Objective To investigate the effect and mechanism of Epimidium on rab-
bits fracture healing. Methods Models of fracture of radius of rabbits were made and di-
vided into experimental group and control group at random, the former were given Epimid-
ium and the latter were given tap water. The difference of fracture healing of two groups
was observed by X-ray、tissue morphologic and immunohistochemisty of TGF-β1、VEGF.
Results Growth of callus、bony remodeling and recanalization of medullary cavity of exper-
imental group were earlier than control group; dyeing of immunohistochemisty of TGF-β1
and VEGF of experimental group was more density than control group in 24 days; dyeing of
VEGF was similar between two groups in 34 days; dyeing of immunohistochemisty of
TGF-β1 and VEGF was similar between two groups in 42 days. Conclusion Epimidium
can promote fracture healing of rabbits by enhancing expression of TGF-β1 and VEGF、pro-
moting regeneration of vascellum、 proliferation and differentiation of osteoblast and chon-
drocyte、advancing quantity and activity of osteoclast.