Objective To study the prophylactic
effects of ginger on motion
sickness in canines and its influences on the vision vestibular
interactions in guinea pigs Methods Using a double blind, placebo controlled design,
effects of ginger extract in 3 dosages (7 8 mg/kg, 3 6 mg/kg and 1 8 mg/kg), theohydramine (3 2 mg/kg) and phencynonate hydrochloride (PCH) (0 2 mg/kg) on motion
sickness (MS) in canines and VVOR in guinea pigs were examined Vomitting incidence was used as index for sensitivity of MS induced by eccentrical oscillation in a triangular velocity mode for 33 min, and beats, slow phase velocity and gain were used as indexes for evaluating vision vestibular interaction nystagmus induced by vertical oscillation with light strips surrounded Results As compared with placebo group, vomitting incidence in 3 ginger groups were significantly lower, and the vomiting incidences in 2 higher dosage (7 8 mg/kg, 3 6 mg/kg) ginger groups were significantly lower than those of theohydramine group and PCH group As compared with those of control group, no significant change of the indexes of VVOR in medication groups were found Conclusion It is suggested that ginger can be effectively used for prophylaxis of MS without significant effect on vision vestibular interaction