Objective To prepare the
trimebutine maleate gastric mucoadhesive
microspheres by the method easy to be industrialized.Methods The microspheres were prepared by an extrude-spheronization method.The
mucoadhesion was evaluated via counting the microspheres retaining on the gastric mucosa.In vitro the drug release was also studied.The factors influencing the mucoadhesion and the drug release such as thermal treatment,CP content,SA-CP/EC ratios,TM content,particle size were also studied respectively.Results While the CP content was increased,both the mucoadhesion and dug release rate of the microspheres increased.The more the
tm content was,the worse the mucoadhesion was and the faster TM released.The mucoadhesion of the microspheres was also reduced when the
particle size was
increased and the release slowed.Both the retaining time in the stomach and the action intensity of the optimized formulation increased.Conclusion The microspheres had a good mucoadhesion and sustained release for 8h when the TM content was≤20%,the particle size was between 500～900 μm and the CP content was 13.30%.
More abstracts about the Preparation of trimebutine maleate gastric mucoadhesive microspheres by the extrusion-spheronizatio