OBJECTIVE To investigate the releasing process and the pharmacokinetics of Gegen Huangtong dripping pills in rabbits. METHODS Twelve rabbits were divided into two equal groups. Single oral administration of isoflavones (100 mg·kg-1) as Gegen Huangtong dripping pills or Yufeng Ningxin tablets was taken. MCP86 was used to calculate the pharmacokinetic parameters and the absolute bioavailabili-ty. RESULTS The main pharmacokinetic parameters of the dripping pills and the tablets were as follows: AUC0-24 599.7 and 294.6μg·h·mL-1; tmax 0.81 andl.70h; t1/2Ka 0.62 and 0.43 h; Cmax 0.56 and 0.19μg·mL-1, respectively. The plasma concentration-time course of Gegen Huangtong dripping pills and Yufeng Ningxin tablets in rabbits was best fitted to an open two compartment model. The absolute bioavail-ability of the dripping pills was 203.5% . There were significant differences for AUC0-24, Cmax and tmax between the two groups. CONCLUSION Gegen Huangtong dripping pills has better bioavaiability and can release drugs quickly. The study shows the rationality of preparing dripping pills and provide the basis for its quality evaluation in human body.