Objective To study the protective effect of reseratrol on BCG+LPS induced
acute hepatic injury in mice. Methods 60
mice were randomly divided into six groups,namely normal group,model group,low,middle and high dosage
resverratrol groups and a positive control group.The doses of 30mg/kg,15mg/kg and 7.5mg/kg were injected into the stomach of the mice in resverratrol groups,the dose of 150mg/kg of biphenyldicarboxylate was injected into the stomach of mice in positive control group and the same volume of saline was injected into he stomach of mice in normal and model groups for a period of 10 days.The mice in model group and three resverratrol groups were intravenously given BCG-LPS through tail;while the mice in normal group were intravenously given the same volume of saline through tail.The eye balls of mice were removed and blood collected 16 hours after intravenous infection of LPS,then the activity of serum aspartate transminase,alanine transminase,superoxide dismutase,nitrogen monoxide and the contents of serum malondialdehyde were measured by colorimetry. Results Resverratrol can significantly reduce BCG+LPS induced acute hepatic lesion to mice by decreasing serum aspartate
transminase and alanine transminase and enhancing the activities of superoxide dismutase and the content of nitrogen monoxide in liver tissue and then reducing the content of malondialdehyde in liver tissue. Conclusion Resverratrol possesses the effect of preventing acute hepatic lesion to mice induced by BCG+LPS.
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