Objective to explore the therapeutic efficacy of kangqianerhao on murine schistosomiasis liver fibrosis and its effect on the expression of Hepatic PDGF.Methods 50 mice with schistosomiasis were divided into 5 groups.2 groups was untreated as the control groups.Praziquantel group was treated only with praziquantel;the combined therapeutic group was treated with praziquantel and kangqianerhao;zhongyao group was treated only with kangqianerhao.the histological changes were observed by HE staining.The expression of Hepatic PDGF and α-SMA positive signs was detected by immunical histochemistry,the collagen fibre was measured by massion staining through graphic computing.Results the reversal of the hepatic fibrotic tissue in the combined therapeutic group is better than the another two therapeutic group;the expression of Hepatic PDGF and α-SMA positive cells and the amount of collygen in this group decreased more obviously than other groups respectively(P<0.05);their expression and fibre in zhongyao group had no marked difference compared with the control groups(P>0.05).Conclusion the therapeutic efficacy of zhongyaofufang is not obervious but it can significantly reverse the hepatic fibrosis if combined with praziquantel;the therapeutic efficacy may be achieved by relieving the inflammal reaction and reducing the expression of hepatic Hepatic PDGF and α-SMA positive cells in murine schistosomiasis liver fibrosis.