Objective To study the effect of Dendrobium candidum Wall.ex Lindl drop(DCWD) on
hematopoiesis of
irradiated mice.Methods One hundred and twenty-five BALB/C
mice were divided into normal control group,irradiation-injured
group and DCWD
groups which were divided into three groups according to the dose of DCWD.Before whole-body
irradiation with 8.0 Gy or 5.0 Gy 6 mV X-ray,the BALB/C mice were supplied with DCWD once a day for 10 days.After being irradiated,these mice were continued to be given DCWD until they were died or putted to death.The survival condition of mice irradiated by 8.0 Gy X-ray was observed,and the peripheral white blood cells(PWBC),the bone marrow nucleated cells(BMC) and the spleen index in mice irradiated by 5.0 Gy X-ray were detected.Results The mean survival time of mice in each group irradiated by 8.0 Gy X-ray was 10 days or less than 10 days,significantly shorter than the normal control group (P<0.01).But the DCWD groups survived longer than irradiation-injured group for 3～4 days (P<0.01);PWBC,BMC and the spleen index of mice irradiated by 5.0 Gy X-ray were descended markedly,but they were higher in the DCWD groups than the irradiation-injured group (P<0.05),and recuperated quickly,however,the difference had no statistical significance between DCWD groups.Conclusion DCWD can notablely prolong the mean survival time and improve the survival rate of irradiated mice,and remarkably increased their PWBC,BMC and the spleen index;DCWD has certain protective effect on radiation-injury,and its mechanisms may be related to promoting the recovery of hematopoiesis.
More abstracts about the Effect of Dendrobium candidum Wall.ex Lindl drop on hematopoiesis of mice with radiation injury