Objective: To explore the
mechanism of Qingx-iang San (QXS) for experimental colitis. Methods: 60 cases were allocated to
alcohol group,model group (MG),low dosage of QXS group (LDG),moderate dosage of QXS group,high dosage of QXS group and salazopyrin group,each group 10 rats,the pathogenic damage of colic tissue,the content of myeloperoxidase (MPO),the superoxide dismutase (SOD),malondialdehyde (MDA),
nitric oxide (NO) and nitric oxide synthase (NOS) in the colon were observed.Results: The body weights of various group after modelled were markedly decreased,but increased gradually after 3 days.In the third day,the differences were significant or very significant ( P < 0.05,P < 0.01) in other 4 groups except LDG.In the 7th day the difference of body weight was significant (P < 0.05) between drug groups and MG,and MPO activity was lower in drug group than in MG ( P < 0.05).The scoring of histological damage was significantly different ( P < 0.05,P < 0.01),indicating that the pathologic damage was reduced.SOD,MDA,NO and NOS of colic tissue in rat models and drug groups were significantly different ( P < 0.05,P < 0.01).It is indicated that QXS can decrease the content of MPO,MDA,NOS and NO in intestinal tissue and increase the value of SOD.Conclusion: The
mechanism of QXS may be related to the decrease of expression level of MPO,MDA NOS and NO and increase of expression level of SOD in rats with experimental colitis.