Objective:To observe the intervention of Liuwei Dihuang pill(LDP) on therapeutic effectiveness and adverse reaction of hormonotherapy and immunosuppressive agent in treating systemic lupus erythematosus.Methods:Patients divided in two groups were medicated with initial dose of prednisone 1mg/kg once a day at 8 am in the morning.After 8 weeks,Medication the dose of prednisone was decreased by 5.0mg every 2 weeks till 30mg/kg per day.Then the prednisone was decreased gradually.The patient of lupus nephnitis were injected cyclophosphamide(CTX) 0.8g once a month.At the same time,the treated group was administrated LDP 8 capsules 3 times per day.Results:Therapeutic effect in the treated group was significant better than that in the control group 96.67%,80.33%(P<0.05).Mouth ulcer,liver insufficiency,disorder of mensis and complement C3,24-hour proteinura were improved(P<0.05,P<0.01).However,as compared with the control group,the improvement was better,and the recurrent rate was lower(P<0.05) in the treated group.Scores of Yin-deficiency caused excessive fire syndrome and incidence rate of adverse reaction in the treated group were lower than those in the control group(P<0.05,P<0.01).Conclusions:LDP can markedly improve the therapentic effectiveness and counteract the adverse reaction of hormonotherapy and immunosuppressive agent in treating systemic lupus erythematosus,and reduce the recurrence of the disease.