Objective It is to observe the action of prevention and treatment of
Guizhi Fuling capsule on
cyclomastopathy.Methods Experimental
cyclomastopathy rat model was made with intramuscular injection of estrogen for 25 d and progestin for 5 d respectively.
Guizhi Fuling capsule was given after three weeks model making and lasted four weeks.The levels of E_2,P and PRL in plasma were determined.The height of the second nipple of rats was measured before and after model making.The patho-change of hyperplasia of mammary glands was observed under microscope.The changes of hyperplasia of mammary glands in every group were observed.Results Guizhi Fuling capsule could remarkably reduce the nipple height of experimental hyperplasia of mammary glands rats,inhibit the hyperplasia of mammary glands,reduce the content of E_2 and P,and increase significantly E_2/P.But it couldn't affect PRL well.Histopathology examination showed that Guizhi Fuling capsule could reduce the hyperemia and edema of hyperplasia of mammary glands rats,decrease the number of alveolus in lobules of mammary gland,reduce the layer of gland epithelial proliferation,inhibit the secretion of alveolus and improve the degree of vessel epithelial proliferation.Conclusion Guizhi Fuling capsule has the function of prevention and treatment on
cyclomastopathy.