Objective To survey and compare the in vitro
bacteriostatic effects of domestic and imported
piperacillin/tazobactam on Pathogenic
bacteria commonly encountered in the clinic. Methods Bacterial suspensions were separately prepared for each of the 336 strains of bacteria to be tested.Escherichia coli 25922 and Pseudomonas aeruginosa 27853 surved as the quality control bacteria strains.The in vitro
bacteriostatic effects of various drugs were assayed with the doubled agar dilution method.Sensitivity of bacteria to drugs was calculated according to the marginal antibiotics' concentration to which the bacteria were sensitive. Results Domestic
piperacillin/tazobactam was shown to have excellent bacteriostatic effects on Klebsiella pneumoniae I super broad spectrum β-lactamase positive(ESBLs+),K.pneumoniae(ESBLs-),E.coli(ESBLs+),E.coli(ESBLs-) and a fairly good inhibitory effect on P.aeruginosa.Piperacillin/tazobactam was also shown to have the best in vitro bacteriostatic effects as compared with those of cefoperazone/sulbactam(CFP/SUB),cefotaxime/sulbactam(CTX/SUB),amoxicillin/clavulaniatepotassium(AMO/CLK),and ampicillin/sulbactam(AMP/SUB).Besides,the enterobacteriaceae manifested almost the same sensitivity to domestic and imported piperacillin/tazobactam and the 2 kinds of the drug showed equivalent bacteriostatic effects on P.aerllginosa. Conclusion Piperacillin/tazobactam was shown to have excellent in vitro bacteriostatic effects and domestic and imported products of the drug were comparable in this respect.