Search
×

Sign up

Use your Facebook account for quick registration

OR

Create a Shvoong account from scratch

Already a Member? Sign In!
×

Sign In

Sign in using your Facebook account

OR

Not a Member? Sign up!
×

Sign up

Use your Facebook account for quick registration

OR

Sign In

Sign in using your Facebook account

Shvoong Home>Medicine & Health>Pharmacokinetics and bioequivalence assessment of phenoxymethylpenicillin potassium tablets in Chine Review

Pharmacokinetics and bioequivalence assessment of phenoxymethylpenicillin potassium tablets in Chine

Article Review   by:TsingHua     Original Author: Journal of China Pharmaceutical University
ª
 
Aim:To establish a LC-MS/MS method for study of pharmacokinetics and bioequivalence of phenoxymethylpenicillin potassium tablets in healthy Chinese male volunteers.Methods:Plasma samples were precipitated with methanol after benzylpenicillin was added as internal standard.Chromatographic separation was achieved on a Waters Symmetry C_(18) column and the mobile phase consisted of methanol and ammonium acetate(pH 5.1)(50∶50).LC-MS/MS was performed in the selected reaction monitoring(SRM)mode.A randomized cross-over design was performed on 20 healthy volunteers.Results:A linear calibration curve for assay of phenoxymethylpenicillin potassium in human plasma was obtained in the range of 0.05~20 μg/mL(r=0.999 8)with the limit of quantitation of 50 ng/mL and the absolute recoveries of at least 90%.The main pharmacokinetic parameters after po a single dose of 500 mg phenoxymethylpenicillin potassium test and reference tablets were as follows:c_(max)(10.36±3.67)and(11.70±4.67)μg /mL;t_(max)(0.8±0.4)and(0.6±0.3)h;t_(1/2)(0 .92±0.25)and(0.92±0.25)h;AUC_(0-8)(13.58±2. 22)and(13.17±2.70)μg·h/mL;AUC_(0-∞)(13.62±2.21)and(13.22±2.70)μg·h/mL,respectively.Therelative bioavailability of the test compared to reference tablets was(107.1±27.7)%.Conclusion:The phenoxymethylpenicillin potassium tablets are bioequivalent to the reference tablets of equivalent doses.
Published: February 25, 2006   
Please Rate this Review : 1 2 3 4 5
Translate Send Link Print
X

.