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Shvoong Home>Medicine & Health>Protective effect of astragalusangelica mixture(黄芪当归合剂) on ischemic acute renal injury in rats Review

Protective effect of astragalusangelica mixture(黄芪当归合剂) on ischemic acute renal injury in rats

Article Review   by:TsingHua     Original Author: Chinese Journal of Integrated Traditional and Western Medicine in Intentire Critical Care
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Objective: To investigate the protective effects of astragalusangelica mixture(黄芪当归合剂) on apoptosis of renal tubular epithelium in rats with experimental ischemic acute renal injury.Methods: (Experimental) acute(ischemic) renal injury model of rats was induced.Levels of blood urea nitrogen(BUN),serum creatinine(Cr) and Nacetyl amino glucosidase(NAG) in urine were detected at different time points of ischemia for(30 minutes) and reperfusion.The cell morphologic changes of renal tissue were observed by hematoxylin and eosin(HE) staining.Expressions of Bcl2 protein and Bax protein were detected by(immunohistochemistry) and the effect of astragalusangelica mixture on it was observed.Results: Cell apoptosis was obvious in kidney in acute(ischemic) renal injury.Bcl2 and Bax were mainly expressed in proximal and distal convoluted renal tubules,and much less expression in kidney glomerulus.The expressions of Bcl2 mRNA,Bax mRNA and Bcl2/Bax ratio(increased) in the kidney with acute ischemic injury.Compared to the ischemia/reperfusion(injury) group,the expression of(Bax mRNA) increased,Bcl2/Bax ratio decreased,and the renal pathological damage was ameliorated in the group treated by astragalusangelica mixture.(Conclusion): Astragalusangelica mixture has protective effects on injuried kidney,the mechanisms may be(related) to the decrease of Bcl2/Bax ratio.
Published: January 28, 2006   
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