Objective To investigate the effect of
Capsule Fuyuan Yugan on rat fatty livers induced by high fat feeding. Methods Animal
models were established by feeding high caloric diet and was administered
Capsule Fuyuan Yugan or Dongbao Gantai as a control.serum activities of liver-associated enzymes,blood lipids,liver triglycerides and the liver histology of rats of all groups were assayed.Flow Cytometry and immunohistochemistry technique were used to detect the apoptosis of hepatocytes and the expression of Bcl-2,Bax in hepatocytes,respectively.Results The levels of serum activities of alanine aminotransferase(ALT),aspartate aminotransferase(AST),total cholesterol(TC),triglycerides(TG) and liver triglycerides in the different dose groups of Capsule Fuyuan Yugan were
significantly lower than fatty liver model group and were similar to those of the normal group.The rate of apoptosis in treatment groups was significantly lower than that in fatty liver model group.The expression of Bcl-2 in treatment groups was significantly higher than that in fatty liver model group(P< 0.05),and the expression of Bax in treatment groups was significantly lower than that in fatty liver model group(P< 0.05).Conclusions Capsule Fuyuan Yugan might be effective in treating rat fatty liver induced by high fat feeding.