Objective To observe the effect of Naomaitai Capsule on the learning and memory abilities and cerebral lipid-peroxidation
in rat with
Vascular Dementia(Vd).Methods Two VD models were(established).The first one was produced by occlusion of bilateral common carotid arteries in rats with the(following) steps: ischemia 20 min—reperfusion 10 min—ischemia 20 min.The
learning and memory abilities were tested by Y type maze.Meanwhile,malondiadehyde(MDA) content and superoxide dismutase(SOD) activity in brain tissue of ischemia-reperfusion rats were measured.The second model was formed by injecting thrombin NS solution into internal carotid artery.The learning and memory abilities were studied by Y type Maze.The content of Evans blue in brain tissue was measured.Results In the model caused by cerebral ischemia-reperfusion,Naomaitai Capsule significantly improved the learning and memory abilities((P<)0.01),increased the activity of SOD(P<0.01),and reduced the content of MDA in brain tissue((P<)0.05,0.01).In the model caused by multiple cerebral infarction,Naomaitai Capsule significantly improved the learning and memory abilities(P<0.05,0.01) and reduced the content of Evans blue in brain tissue(P<0.01).Conclusion Naomaitai Capsule can improve the learning and memory abilities of the rats with VD and reduce the injury caused by cerebral lipid peroxidation