Objective To report the therapeutic effects of Han-Dan-Gan-Le(HDGL) in the
treatment of As-induced liver
disorders in humans. Methods Twenty chronic arsenic-exposed patients were selected based on the history of As exposure, symptoms of liver disorders, and serology excluding HBV and HCV infection. HDGL was administered at the dose of 1.2 g, tid, po for 3 months. Results After the treatment, all the patients achieved significant improvement of the gastrointestinal tract symptoms, the abdomen pain disappeared, and serum levels of ALT was decreased(P < 0.05).
Histology from liver biopsy samples was performed before and at the end of the 3-month treatment. Before treatment, histological examination showed widespread parenchymal cell vacuolation,
focal necrosis, inflammatory cell infiltration in focal area and a few foci of fibrosis. After HDGL treatment, hepatocellular vacuolation was greatly ameliorated and focal necrosis and inflammation were not evident, and no liver fibrosis was found. The degree of hepatic histology in this before-group was significantly
decreased compared with that in the after- group (P < 0.05). No apparent side effects were observed to stop the HDGL treatment. Conclusions This preliminary study has demonstrated that HDGL is very effective in the treatment of As-induced liver disorders, as evidenced from histopathology, appetite and other clinical improvements.
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