Objective To observe the anti-tumor effect of Chinese medicine,
Fuganchun 6(FGC-6) and the synergetic effect of FGC-6 and
5-Fu on mouse hepatoma.Methods Transplanted H_(22) tumor in mice were made and the mice were randomly divided into 6 groups: model group,high and low 5-Fu dose treated groups,high and low FGC-6 dose treated groups and combined both drugs treated group.These mice were treated for 10 days.The weight changes of H_(22) hepatoma were observed, the target cell-killing
activity of NK cells,the lymphocyte proliferation activity and the IL-2 induction level of murine splenocytes were assayed,respectively.Results Growth of H_(22) tumor was markedly inhibited by FGC-6 and 5-Fu.Compared with the model group,the difference was significant(P<0.05).The q,value which calculated with Jin Formula was 1.37,bigger than 1.15.Compared with the model group,high FGC-6 dose or combined both drugs increased the target cell-killing activity of NK cells,the lymphocyte proliferation activity and the IL-2 products(P<0.05),but high 5-Fu dose decreased them(P<0.05).Conclusion FGC-6 can inhibit the growth of transplanted H_(22) tumor.The mechanism of its action may be related with improving the immunity of tumor-bearing mice.Furthermore,there is synergetic antitumor effect when low FGC-6 dose and low 5-Fu dose are combined to treat the mice.