Objective:To study the changes expression of
plasminogen activator system(urokinase plasminogen activator,urokinase plasminogen
activator receptor,plasminogen activator inhibitor-1) in rats liver tissue with blood stasis type of hepatic fibrosis after treated with
liver-softening Granules.Methods: The rats were randomly divided into normal group,blood stasis group and liver-softening Granules group.The following parameters were observed and detected: the sign of blood stasis,and the protein expression of uPA,uPAR,PAI-1 in hepatic tissue(by immunohistochemical,enzyme linked immunosorbent assay,et al).Results : After modeled,the rats appeared significantly sign of blood stasis in blood stasis group.Compared with the normal group,the model group' sign score were higher,and the differences was significant.And treaded by liver-softening Granules,the blood stasis sign had decreased significantly.uPA、uPAR、PAI-1 were expressed in liver tissue.The expression of them was higher in blood stasis group than in normal group,and the differences were significant.The expression of them was lower in liver-softening Granules group than in blood stasis group,and the differences were significant.Conclusions:There were expression of uPA、uPAR、PAI-1 in rats'liver tissue.The expression of uPA、uPAR、PAI-1 were higher in the type of blood stasis hepatic fibrosis rats.After liver softening-Granules treated,the expression of them were decreased.Maybe liver softening-Granules treated hepatic fibrosis by regulating the
plasminogen activator system and hasten the fibrin dissolve.