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Change of Bone Metabolism in Rats with Nephrotic Syndrome and the Role of Astragalus and Angelica Mi
To investigate the change of bone metabolism in rats with nephrotic syndrome(NS)and the role of Astragalus and
Angelica mixture(A&A). Forty male SD rats(six weeks old)were randomly divided into five groups:control group,NS model group,NS group treated with A&A,NS group treated with dexamethasone(Dex),NS group treated with A&A and Dex.Urine protein,serum biochemical levels and the femur length were measured.The bone mineral density(BMD)of whole part of femur was measured by Hologic ODR-2000+DEXA.Serum osteocalcin(OC),aminoterminal propeptide of type I procollagen(PINP)and carboxyterminal telopeptide of type I collagen(ICTP)levels were assayed by radioimmunoassay technique. The length of femur of NS group treated with A&A and NS group treated with A&A and Dex were higher than those in NS model group and NS group treated with Dex,respectively(P < 0.05 and P < 0.05).The length of femur of NS group treated with Dex was lower than that of NS model group(P < 0.05).The length of femur of NS model group was lower than that of control group(P < 0.05).The BMD of femur in NS model group was lower than that of control group(P < 0.01).The serum levels of OC and PINP in NS model group were lower than those in control group(P < 0.01).The serum levels of OC and PINP in NS group treated with A&A and NS group treated with A&A and Dex were higher than those in NS model group and NS group treated with Dex,respectively(P < 0.05 and P < 0.01,respectively).The serum levels of OC and PINP in NS group treated with Dex were lower than those in NS model group(P < 0.05).The serum levels of ICTP in NS group treated with Dex were higher than that of NS model group(P < 0.05). The abnormality of bone metabolism exists in nephrotic rats.Dexamethasone treatment can aggravate this abnormality,which can be improved by Astragalus and Angelica mixture.
Published: January 20, 2006
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