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Shvoong Home>Medicine & Health>The Molecular Mechanism of Puerarin on the Protection of Cerebral Ischemia injury in rat Review

The Molecular Mechanism of Puerarin on the Protection of Cerebral Ischemia injury in rat

Article Review   by:TsingHua     Original Author: Guangxi Medical Journal
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Objective To study the protection of puerarin and its effect on the expressions of HSP_ 70 and Fas as well as its protected molecular mechanism in rat's cerebral ischemia injury.Methods Rat models of acute local cerebral ischemia and cerebral ischemia-reperfusion were made by ligated middle cerebral artery.The puerarin was injected into the rat's belly before ligating the cerebral artery.The histopathological damage was assessed and the expressions of HSP_ 70 and Fas protein were detected by histochemistry in SP method.Results In the acute cerebral ischemia injury groups,The number of death neurons were significantly less and the expression of HSP_ 70 was strongly higher in puerarin treated group than that of without using puerarin(P<0.01).While there was no significant difference in Fas expression in both groups(P>0.05).There was negative association between the number of death cells and puerarin interference(P<0.01).In the cerebral ischemia-reperfusion groups,the number of death neurons were significantly less and the expression of HSP_(70) was strongly higher,while the Fas expression was weaker in the puerarin treated group than that of without using puerarin(P<0.01).There was negative association between the number of death cells and puerarin interference(P<0.01).Conclusion Puerarin can prevent the neuron damage after acute cerebral ischemia and reperfusion injury in rats.It can up-regulate the expression of HSP_ 70 to protect the neurons during acute cerebral ischemia.While during the cerebral ischemia-reperfusion injury,it is not only up-regulated the expression of HSP_(70) but down-regulated the expression of Fas to reduce the neuronal apoptosis as well in order to protect the cerebral tissue.
Published: January 15, 2006   
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