Objective To observe the safety of
Kangrongchongji on preventing the disorder of incompatable blood group between mother
and fetus. Methods 20 mice , half male and half female,were fed three times continusly with
Kangrongchongji solution after 12 hour's fast. Each feeding interval was five hours and the dosage was 0.4 mg/10 g.The fur color, weitght,appetite,bowel movement, activity mental state were
observed after seven days feeding.? Wstar pregnant rats were randomly divied into nomal group, small dosage Kangrongchongji group, great dosage Kangrongchongji group and Vitamin AD group. Each pregnant rat was fed in the seventh day of pregnant and fed for ten days continuosly. In the ninteen day of pregnant, the whole pregnant rats were killed. The amount of fetus rat, the apperence, skeleton and viscera of the fetus rats were observed. Results The fur color, weitght,appetite,bowel movement, activity mental state were normal and no dead experimental mouce was observed.Compared with normal group,there were no significant difference of fetus rats in the small and great dosage Kangrongchongji groups in length, body weitht and plaenta weight(P>0.05).There were no malformal fetus rat in Kangrongchongji group and the skeleton was normal in the whole groups. Conclusions Kangrongchongji has low toxicity without malfromation effection.