Objective:To study the effect of Chinese medicine “
Qishenjiangzhi decoction”(QSJZD) on
atherosclerosis (AS) and to elucidate
its mechanism further. Method:Twenty-four healthy male SD rats were randomly divided into 3 groups:control group, model group ,Chinese medicine treated group, The model rats of
atherosclerosis were established by feeding with high cholesterol diet and injecting with vitamin D_2 for 6 weeks. Six weeks later, serum lipid levels of MDA, SOD and lipid were measured for all the rats. HE staining was used to study the pathology change of atherosclerosis. Immunohistochemistry and gelatin zymography were used to detect the expression and activity of MMP-2 in aorta vessel. Result:Comparing the chinese medicine treated group with model group, the serum level of TC, LDL-C and MDA were significantly reduced (P<0.01) , while serum SOD level was obviously increased (P<0.01) .The damage of the aortas in medicine treated group was less severe than that in model group. The expression and activity level of MMP-2 in medicine treated groups was significantly higher than the model groups. (P<0.01). Conclusion:QSJZD could intervene the formation of atherosclerosis, The mechanism might be through suppressing TC, LDL-C and lipid peroxidation, and affecting the activity and expression of MMP - 2.