Objective To investigate the effect of
Dan-shen combined with
Biloba Leaf', 1, 1595726)"; href="/tags/extract-of-ginkgo-biloba-leaf/">extract of Ginkgo Biloba Leaf on
hepatic fibrosis of experimental rats. Methods Concentrated solution of Dan-shen ranged from 2 g/kg to 8 g/kg (equal to raw herb) combined with extract of Ginkgo Biloba L ranged from 1.5 g/kg to 6 g/kg(equal to raw herb) were
administered to chronic hepatic fibrosis
rats . The rats' ratios of net hepatic and body weight were calculated. The pathological change of all the samples and the ultra micro-structure of some samples were observed within 50 days. Results The hepatocyte degeneration, necrosis and the degree of connective tissue proliferation could be reduced as the two agents matched, the hepatic pathological changes of ultra micro-structure were reduced as well. The effect relied on the dosage administered, and which of Dan-shen combined with extract of Ginkgo Biloba L was more notable than the former administered singly (P< 0. 05) . Conclusion All the results confirm that Dan-shen combined with extract of Ginkgo Biloba L can delay or inverse hepatic fibrosis formation effectively, but the effectiveness depends on the dosage administered and efficacy of treatment of rats by middle dose mixture is superior to that by equal-dose Dan-shen, which can be concluded that the two agents are properly matched .
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