Objective: to probe into the effect of
Dimethyl Sulfoxide on operative incision healing of mice locally injuried by doxorubicin
exosmosis, to provide a theoretical basis for clinical nursing. Method: a total of 30 health Kunming mice were made vessel exosmosis on abdomen of right and left sides, and 25 of them were selected randomly. The left side of injured abdomen of 25 mice were categorized into
intervention group with
Dimethyl Sulfoxide, while the opposite sides of the same mouse was categorized into intervention group with sterile pyrogen-free water as control. The remainder of 5 mice were taken as model, with no disposal. And another three healthy mice of Kunming species were selected as normal control. The exosmosis skin and subcutaneous tissues of mice were cut away in operational way five days after operation and with interrupted suture. And 7 days after suturing out, the healing time of incision were observed. Result: there is a significant difference in incision healing between the two groups (P<0.001). However, there were differences in terms of healing time between different groups of mice, except for that between normal and intervention group, model and control group (P<0.05). Conclusion: it showed that Dimethyl Sulfoxide could enhance primary healing of mice's incision injuries induced by doxorubicin exosmosis.