Objective:To evaluate the effects of implantation of controlled-releasing
Radix salvia miltiorrhiza on fracture healing.Methods:Standard
fracture models were established in the middle of right radii of New Zealand healthy white rabbits.42 rabbits were divided randomly into experiment group and control group,~60 mg
controlled-releasing
Radix salvia miltiorrhiza were implanted into the fracture site in experiment group and 60 mg excipient in control group.Radiography,histological and electron-microscopic examination were done respectively.BMD was detected at the 2,4,6 th week after the operation.Biomechanics test was employed at the 5,6 th week after the operation.Results:X-ray films showed fracture healing was earlier in the experiment group than that in the control group.Histological examination showed in the experiment group the transformation of fibrous callus,cartilaginous callus and trabecular bone were faster than that in the control group.The capillary hyperplasia was obvious.The electron-microscopic examination showed all morphological changes facilitated to fracture healing.BMD at fracture site were higher in the experiment group than that in the control group;moreover,the difference of BMD at the 4 th week had statistical significance(P<0.05).The figures of anti-fracture strength in the experiment group were greater at the 5,6 th week,and the difference had statistical significance(P<0.05).Conclusion:Implantation of controlled-releasing Radix salvia miltiorrhiza can accelerate fracture healing.