Objective To study the change in
postprandial plasma P-selectin concentration after a high-fat meal (800 kcal; 50 g fat )
in patients with essential
hypertension (EH) and explore the effect of fluvastatin alone or combined with valsartan. MethodsThirty-three EH patients were studied. The concentrations of plasma triglyceride(TG), total cholesterol, LDL-Cholesterol, HDL-cholesterol and P-selectin in fasting state and 4 hours after a high-fat meal were measured. All patients were randomly assigned to accept routine therapy (control group), fluvastatin (40 mg/d) (fluvastatin group), or combination of fluvastatin (40 mg/d) and valsartan (80 mg/d) on the base of routine therapy for a week. One week later, the high-fat meal test was repeated. ResultsThe
postprandial plasma TG and P-selectin concentrations were increased in all 33 patients with no difference among them. The postprandial plasma P-selectin was significantly correlated with postprandial plasma TG(r=0.427, P<0.05). After treatment, BP was decreased significantly with no changed in TG. Fuvastatin and combined treatment inhibit the postprandial increases in P-selectin while the increases was sustained in the control group
0.05; combined treatment:(147.1±62.9 to 196.5±154.9)ng/mL, P>0.05>. The change in plasma P-selectin concentration was not significantly related to the changes of plasma lipids and blood pressure. ConclusionThe combinationof fluvastatin and valsartan effectively reduced plasma P-selectin concentration