Objective :To observe the effect of Weierkang on the growth factors in the rats with chronic atrophic gastritis. Methods :SD rats were divided into 4 groups,the rats in the CAG model group,high dosage of Weierkang group and low dosage of Weierkang group were fed with alcohol,deoxychlioc acid Na,and ammonia,the process lasted 27 weeks,the rats in the normal group were fed with saline instead.In addition,the rats in the treatment group were fed with Weierkang at the dosage of 65g/Kg/d and 32 5g/Kg/d,the rats in the model were fed with saline,27 weeks later,with HE dyeing,the grade of gastric mucosa atrophy were estimated;with RIA,the amounts of plasma EGF,TGF α,GH,IGF Ⅱ were measured. Result :Rats gastric mucosa in the CAG model group showed moderate or severe atrophy,after preventive treatment with Weierkang,the grade of gastric mucosa atrophy were obviously lessening,compared with the normal group,the amounts of serum EGF,TGF α of the rats in the model group were obviously higher,the amounts of GH,IGF Ⅱ lower;after preventive treatment with different of dosage of Weierkang,compared with the model group,the amounts of plasma EGF,TGF α became always lower,but the amounts of serum GH,IGF Ⅱshowed no significance. Result :It may be one of the mechanisms in the treatment of chronic atrophic gastritis with Weierkang that could lower the amounts of serum EGF,TGF α.