Objective:To explore effects of Tongmaining Capsules on haemorheology and related active factors after internal carotid artery balloon injury in rabbits models of vascular stenosis.Methods:With asepsis operation,internal and external carotid artery was separated,then the balloon was only inserted from external carotid artery to internal carotid artery,and draw back and forth repeatedly for three times in constant pressure of 2 Pa,to result in carotid artery endodermis injury and vascular stenosis.After the doses were given successively for 21 days,the blood were taken from the common carotid artery,and whole blood viscosity,plasma viscosity,corpuscular volume,erythrocyte aggregation index,aggregation area,erythrocyte deformation index,deformation area,content of TXB 2 and 6-keto-PGF 1α in plasma were measured.Results:Compared with the sham operation group,whole blood viscosity,corpuscular volume,erythrocyte aggregation index,TXB 2 in plasma,and content and ratio of TXB 2 and 6-keto-PGF 1α in rabbits of model group increased significantly,but 6-keto-PGF 1α and erythrocyte deformation index decreased significantly.Compared with model group,in Tongmaining Capsules large and middle dose group, whole blood viscosity,corpuscular volume,erythrocyte aggregation index,TXB 2 in plasma,and content and ratio of TXB 2 and 6-keto-PGF 1α decreased significantly,and 6-keto-PGF 1α and erythrocyte deformation index increased significantly.Conclusion:Tongmaining Capsules can promote blood circulation to dispel blood stasis strongly,thus this study provide substantial pharmacological basis about therapy of vascular endodermis injury induced vascular stenosis.