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Effect of Xiaoyao Powder on Ca~(2+) in Hippocampal Synaptosome of Multi - Stress Model Rats
To observe the influence of Xiaoyao Powder on the concentration of Ca2+ in hippocampal synaptosome of multi -
stress model rats. Wistar rats were randomly allocated to five groups: normal control (Group A) , model 1 (Group B), Xiaoyao Powder 1 (Group C), model 2 (Group D), and Xiaoyao Powder 2 (Group E) . All the rats except those of Group A were replicated to chronic multi-stress models. At the meantime, Groups C andE were given the decoction of Xiaoyao Powder, 1.06g each for 21 days and 42 days respectively. Groups A, B and D were administered by gavage the equal amount of normal saline. After the administration, the hippocampal homogenate was taken to detect the concentration of hippocampal synaptic Ca2+ by fluorimetry. Compared with Group A, the concentration of Ca2+ in hippocampal synaptosome of Groups B and C was increased, having significant difference ( P < 0.01). That of Group C was lower than that of Group B (P < 0.01) while that of Group E lower than that of Group C (P < 0.05) . Compared with Group B, the concentration of Ca2+ in hippocampal synaptosome in Group D was markedly decreased (P < 0.05). These observations suggest that the concentration of Ca2+ in hippocampal synaptosome of multi-stress model rats was increased reversibly or partially reversibly, and Xiaoyao Powder can counteract such changes and this effect is positively correlative with the time of medication.
Published: January 01, 2005
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