Quantitative determination method for the contents of Antongding injection Article Abstract
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Published: February 20, 2005
OBJECTIVE To establish different quantitative determination methods for the contents of Antongding injection to adjust mutual accuracy METHODS To eliminate the interference of ingredients,the mathematical separation method was used to establish CPA matrix method and multi wavelength linear regression method of Antongding injection without any preliminary separation At the same time,assay of Antongding injection was carried out using Hebei pharmaceutical standard RESULTS The average recoveries and relative standard deviations of amidopyrine,phenazone and barbital by CPA matrix method were 100 2%,0 54%;100 2%,0 53%;and 100 2%,0 55%,respectively The average recoveries and relative standard deviations of amidopyrine,phenazone and barbital by multi wavelength linear regression method were 100 2%,0 46%;100 7%,0 75%;and 99 99%,1 41%,respectively The data were detected respectively and then statistically analyzed The CPA matrix method was compared with Hebei pharmaceutical standard method.Large quantity of amidopyrine and phenazone showed no significant difference,but the small amount of barbital had significant difference The multi wavelength linear regression method was compared with Hebei pharmaceutical standard method,and the data showed no significant difference CONCLUSIONS The methods are simple,rapid,accurate and precise,and can be used for the determination of Antongding injection