Objective: To investigate the effect of
tetramethylpyrazine on vascular
endothelium function in patients with acute myocardial
infraction(AMI) after thrombolysis therapy. Methods: Eightythree patients with AMI were randomly divided into two groups, 43 were in the treatment group and 40 in the control group. The treatment group was treated with urokinase(1015)×10 5 U in 0 9% normal saline 100 ml infused intravenously within 30 minutes, aspirine 0 3 g orally once a day for 3 days and then 0 1 g once a day for a long time.
Tetramethylpyrazine 240 mg in 0 9% normal saline 400 ml was infused intravenously 10 30 minutes before using urokinase over 1 52 0 hours, once a day for 14 days. The treatment of the
control group was the same as that of the treatment group except tetramethylpyrazine treatment. The recanalized rate was estimated by the standard of noninvasive coronary artery recanalization. The changes of plasma triglyceride(TG) , total cholesterol(TC), high density lipoproteincholesterol (HDLC), low density lipoproteinscholesterol(LDLC) were measured by enzyme methods, and the flow mediated endotheliumdependent vasodilatation was measured by the high resolution ultrasound technique in both groups before and after the treatment. Results: The recanalized rates had no significant difference between the two groups 〔65 12%(28/43 case) vs. 65 00% (26/40 cases), P >0 05〕. Blood lipids had no significant changes before and after treatment. Endotheliumdependent vasodilatation was improved in the treatment group after treatment 〔(6 53±0 41)%〕 compared with that before treatment 〔(2 46±0 21)%〕 and that in the control group 〔(2 51±0 26)%〕, both P <0 05. Conclusion: Tetramethylpyrazine can improve endothelium dependent vasodilatation of patients with AMI after thrombolysis therapy, but has no effect on recanalization and blood lipid metabolism.