Objective To probe the regulation mechanism of the water and salt metabolism in syndrome of
accumulation of dampness in
middle-Jiao from the changes of ADH,ALD,ANP and Na+,K+ inside erythrocyte in rats, and observe the effects of
Pingweisan on them. Methods The syndrome of
accumulation of dampness in middle-Jiao in rats were modeled and rats were divided into four groups:control group, model group, Pingweisan group and self-recovery group. The density of ADH,ALD,ANP and Na+,K+ inside erythrocyte were measured. Results ADH in the model group were significantly higher than in the control group (P <0.01). ALD in the model group were higher than in the control group. ANP in the model group were almost not different from in the control group. After the cure of Pingweisan, ADH 、 ALD and Na+ in Pingweisan group and self-recovery group were significantly lower than in the model group (P <0.01). The ANP and K+ were almost no change. Conclusion The release of ADH in the rats of the syndrome of accumulation of dampness in middle-Jiao were builded up, and the exudation of ALD has the trend of enhancing ADH and ALD regulate the balance of water and electrolyte together so that water and Na+ in body and K+ let out, but ANP doesn't participate in the regulation. Pingweisan can adjust the disorder of water and electrolyte toward balance by removing Na+ and keeping K+ through control of the release of ADH and the exudation of ALD.