Objective In a city scope,to investigate the medication condition of the third generation
cephalosporins (TGC) and the drug
resistance of Gram-negative bacillus isolated from clinics to TGC,so as to provide a necessary reference to scientific and rational use of this kind of antibiotics.Methods Five hospitals with representativeness in our city were chosen as subject,their consumption of TGC and data of clinical sensitivity test during 2000-2002 were used as samples for this study according to the WHO-recommended DDD method (defined daily dose method) to probe into
medication frequency (DDDs) and therapeutic time (days);using paper diffusion and Mic method of Microscan system to make drug sensitive test,judging the data obtained according to the National Committee for Clinical Laboratory Standards 1999 (NCCLS 1999). Results The three years of 2000,2001,and 2002 saw the total medication frequency of TGC was 1 306 400 days,ie,333 500 days,431 200 days and 541 700 days respectively;the three years witnessed that ceftriaxone,cefotaxime,ceftazidime,and cefoperazone had got medication frequencies of 733,900 days,256 600 days,216 500 days and 99 400 days respectively.The three years also found that the Gram-negative bacillus got an average drug-resistance of 40.92%,ie,39.04% for 2000,41.05% for 2001 and 42.58% for 2002.Gram-negative bacillus showed resistance to ceftriaxone,cefotaxime,ceftazidime,and cefoperazone in percentages of 51.43%,46.02%,33.17% and 33.08%. Conclusion Abuse or excessive use of TGC makes high the bacillus′ resistance;the more quicklier the medication frequency increases,the more strong the Gram-negative bacillus′ resistance becomes.It is suggested that attention must be paid to the relationship of high medication frequency with bacillus′ resistance and its harmfulness;scientific and rational use of TGC and lowering their medication frequency can postpone or reduce the occurrence of bacillus′ resistance,insuring the safety and effectiveness of the TGC use.