BACKGROUND:The intelligence retardation in children refers to hypo intelligen ce structure of full intelligence quotient(FIQ) composed of performance intellig ence quotient(PIQ) and verbal intelligence quotient(VIQ).It is verified in some researches that some of compound formulas provide better intervention on it. OBJECTIVE:To observe the effect of yizhi koufuye on intelligence structure in children with intelligence retardation. DESIGN:Homochronous controlled study based on children. SETTING:Pediatric department in a provincial college of traditional Chinese me dicine and one provincial rehabilitation center. PARTICIPANTS:The cases were selected in Rehabilitative Central Hospital in Gan su Province and Clinic of the Hospital Affiliated to Gansu College of Traditiona l Chinese Medicine from January to July 2002.They were 74 students in Fudu Schoo ls in Chenguan District,Lanzhou City,aged varied from 6 to 16 years,diagnosed as intelligence retardation according to CCMD II R proposed Intelligence Retarda tion Diagnostic Standards,and they were able to accept medical and training trea tment and were absent of congenital hereditary chromosome disorders.Of those,47 cases were males and 27 cases females.They were divided into treatment group of 33 cases,the control of 20 cases and simple educational training group of 21 cas es. METHODS:In treatment group of 33 cases,yizhi koufuye was administrated and was taken 15 mL each time for children younger than 10 years old,20 mL for those be tween 10 to 14 years old and 25 mL for those over 14 years old. In addition,the special educational training was applied.In the control of 20 cases, oral applic ation of piracetam was prescribed,0.4 g per time,3 times a day and the special e ducational training was applied additionally.In simple educational training grou p of 21 cases,the children only received special education same as those in trea tment group and the control.
Three months made one session.Chinese Wechsler Inte lligence Scale for Children(C WISC) and specific devices were used to assess FI Q and PIQ and VIQ in classified IQ in 3 groups before and after treatments,and t he control comparisons were carried on among groups. MAIN OUTCOME MEASURES:Improvement of FIQ and improved values of VIQ and PIQ in 3 groups. RESULTS:Totally 74 cases were selected and no one lost. Improvement of FIQ:In treatment group,there were 44.7±9.8 and 51.8±11.5 before and after treatment r espectively,t=2.701,P< 0.01;In the control,there were 43.8±14.0 and 51.0±13.6 before and after treatment respectively,t =1.680,P >0.05;In simple educational t raining group,there were 41.6±7.8 and 45.2±10.6 before and after treatment res pectively,t =1.561 and P >0.05. Improved values of VIQ:It was 8.1±5.5 in treatm ent group,5.3±3.9 in the control and 4.8±4.8 in simple educational training gr oup.P< 0.05 compared with the results in treatment group.Improved values of PIQ: It was 4.0±3.6 in treatment group and P< 0.05 compared with 1.7±2.2 in the co ntrol and simple educational training group. Improving extent of VIQ was 8.1±5. 5 and of PIQ was 4.0±3.6 in treatment group,P< 0.01. CONCLUSION:Yizhi koufuye improves markedly FIQ of children with intelligence r etardation and for the classified IQ,the improving extent of VIQ is superior to that of PIQ.