Objective> To study the effect of
Yihuo Qingyi Decoction (Yqd) on myocardial cell injury of severe acute
pancreatitis (SAP)
rat.
Forty-five male SD rats were randomly divided into three groups: normal group(group A, n =15), control group (group B, n =15) and treatment group (group C, n =15). SAP model was established. Blood of the three groups was obtained respectively 6 hrs,12 hrs and 24 hrs after operation to measure the level of AMY, CIP, CK-MB, TNF-α, IL-6, CTn1. Six hours after operation, T wave and ST segment of ECG showed abnormal. Serum levels of AMY, CIP, CK-MB, TNF-α, IL-6, CTn1 went up continuously. In the treatment group, T wave and ST segment depressed compared with those in the control group ( P < 0.01 ), and the levels of AMY, CIP, CK-MB, TNF-α, IL-6, CTn1 in blood obviously decreased compared with those in the control group ( P < 0.01 ).TNF-α, IL-6 might be important transmitters which related to myocardial damage in SAP. Monitoring TNF-α, IL-6, CTn1 might foretell the degree of myocardial hurt in SAP. YQD can lower the serum levels of TNF-α and IL-6, improve micro-circulation, depress the pancreas enzyme activation which attributes to micro-circulation dysfunction, and alleviate degeneration and necrosis. YQD is one of the ideal medicines to treat myocardial damage in SAP.