Objective: To observe the protective effect of traditional Chinese medicine
cyclovirobuxine D(CVBD,环维黄杨星D) on cerebral ischemic
injury induced by renovascularhypertension prone to stroke in rats.Methods: The rat renovascularhypertension model prone to stroke was established by clipping bilateral renal arteries with silver loop clips; then a nylon suture was used to ligate an unilateral middle cerebral artery, its occlusion was achieved and a model of cerebral ischemia/reperfusion was established. The neurological behavior, the volume of water content in the brain, and the size of cerebral infarction area were observed 6 hours after ischemia and 6, 72, 168 hours after reperfusion CVBD was applied in
treatment group and normal saline, in the control group. The results were compared between the two groups. Results: In the control group, cerebral water content were(82.32±1.61)%, (83.88±1.48)% and (81.61±1.31)% after 6, 72 and 168 hours of reperfusion respectively. Compared with the control group 〔(79.08±1.04)%, (80.84±1.27)% and (78.37±1.16)%〕, the cerebral water content of CVBD treatment group declined significantly (P<0.05 or P<0.01), and the rates of cerebral infarction area 〔(14.41±1.26)% and (18.41±1.62)%〕 were also smaller in the treatment group than that of the control subgroups 〔(21.42±1.61)% and (22.77±1.48)%〕 after 72 and 168 hours of reperfusion (both P<0.05).Conclusion: CVBD has markedly protective effects on experimetal rats with cerebral injury induced by ischemia/reperfusion.