Objective To study the alternation of apoptosis in rat spinal cord after continuous compression injury,and to find out the
effects of
“Jingzheng Recipe” and “Weizheng Recipe” on GFAP at local chronic
spinal cord injury.Methods Screw was used to dill into spinal cord through anterior vertebral body.After operation the screw was remained for 30 days,and then the method of in situ end labeling TUNEL was used to check the changes of apoptosis in compressed foci.Results After spinal cord compression,the apoptosis of neurocyte and glial cell in both grey and white matter was significant,especially in white matter.After administration of “Jingzheng Recipe” and “Weizheng Recipe”,the amount of positive staining neurocyte and glial cell decreased and its staining was weakened.Compared with sham group,the apoptosis number of each group increased significantly( P <0.01).And there was a significant difference between groups of different compression degrees( P <0.05).There were also significant differences between treatment and model groups and among treatment groups ( P <0.01) .And the “Weizheng Recipe” had better effects than “Jingzheng Recipe”.Conclusions After continuous compression injury of spinal cord,the apoptosis of neurocyte and glial cell in compression location is significant.“Jingzheng Recipe” and “Weizheng Recipe” have good effects in inhibiting the apoptosis of neurocyte and glial,the latter Recipe with better effects.