Objective: To study the protective effect of labiate on rat cells post burn. Method: 68 Spregue - Dawley rats were randomly
divided into control group (A), burn group (B) and treatment group (C). Rats in groups B and C were burned to full- thickness with a total area of 20%TBSA. Dynamic changes in the plasma levels of endothelin (ET), nitric oxide (NO) and
lactic dehydrogenase (LDH) were determined at different time points post injury and in the meantime, malondialdehyde (MDA) and superoxide dismutase (SOD) levels in
intestine tissue were also determined. Result: 1. In groups B and C, the levels of SOD in intestine tissue were lower than that in group A. But the difference between group A and group C was not significant. 2. In groups B and C, the levels of MDA in intestine tissue were much higher than that in group A (P<0. 05); and in group C, MDA level was much lower than in group B (P<0. 05). 3. The plasma levels of ET, NO, and LDH in groups B and C were increased obviously post injury (P < 0. 05), but in group C, these values were lower than that in group B. Conclusion: Labiate has protective effect on rat cells post burn. It increases the level of SOD and decreases that of MDA, ET, and NO in plasma and as a result, it lessens the damage of cells. Therefore, it may also lessen the systemic inflammation reaction syndrome and multiple organ dysfunction syndrome poet thermal injury.