AIM: To study the influence of
magnesium chloride of different dosage on platelet
aggregation and thrombosis, and compare
the effect with that of aspirin. METHODS: The experiment was carried out in the laboratory of Department of Pharmacology,Jinzhou Medical College from June to July 2004.Fifty male SD rats were randomly divided into 5 groups: saline control group, aspirin control group,
magnesium chloride of low, middle and high dosage groups.All the rats were administrated via caudal vein, once a day for successive 3 days. Platelet
aggregation was induced by adenosine diphosphate (ADP), collagen and thrombase,The rate of platelet aggregation was assayed by turbidity method with a multi-functional intelligence blood condense-meter of TYXN-96 series.The thrombotic mass was determined with the thrombotic method. RESULTS: All the 50 rats were involved in the analysis of results. ①The inhibitive rates of platelet aggregation induced by ADP, collagen and thrombase were better in the magnesium chloride of high dosage group (55.5%,46.1%,42.4%) than in the middle and low dosage groups (64.3%,59.3%,51.2%; 49.5%,30.4%,20.0%), which were all better than those in the aspirin control group (39.0%, 55.3%, 53.2%).②The thrombotic mass was reduced by 65.8%and 55.7%in the magnesium chloride of high and middle dosage groups respectively, and those in the low dosage group and aspirin control group were almost the same (50.7%, 49.1%). CONCLUSION:The results indicate that the inhibitive effect of magnesium chloride on platelet aggregation and thrombosis may be related with its inhibition on the activation of platelet and the activity of thrombase, but the definite mechanism still needs further study.