To study the effect of TX0201 on Alzheimer's Disease rat model. We mainly observed the oxidative damage and the
energy metabolism
of the rats. Methods: We injected Aβ25-35 into amygdalas of both sides to make the "AD" rat model. We detected the active of SOD?GSH-PX and the content of MDA?ROS in cortex by using spectropho meteric analysis;and in situ hybridization was used to detect the
expression of COIImRNA in cortex and hippocampus. Results: Compared with the normal rats, the active of SOD?GSH-PX in the "AD" rats' cortex was markedly decreased and the content of MDA?ROS in the "AD" rats' cortex was obviously increased. Meanwhile,the expression of COIImRNA was evidently reduced. As for the rats in TX0201 group and E_2020 group comparing with the "AD"rats, the active of SOD was obviously enhanced and the content of MDA?ROS was markedly decreased. However,the active of GSH-PX only had the trend of increasing. Meanwhile,comparing with the "AD" rats, the expression of COIImRNA was obviously increased in the rats' brain of TX0201 group and in E_2020 group the expression only had the trend of increasing. Conclusion: We found that TX0201 had the effect of improving the oxidative damage condition and the abnormal
energy metabolism in the "AD" rats' brain.Thus,the recipe could prevent the occurrence and the development of AD.