To compare the renal toxicity of
tripterygium wilfordii, Caulis and leonurus in rats. Methods:
Tripterygium wilfordii, Caulis
hocquartiae and leonurus were given to rats per oral. After 90 days successive administration, 2/3 of the total rats were sacrificed, and changes on the general states of health?urine routing?urine small proteins?liver function?renal function?renal pathomorphology were observed. The rest were experienced 30 days restoration period, and repeated the detection of the above-mentioned indexes to observe the conditions of restoration?secondary and lingering effects. Results: The high and low-dose of
Tripterygium wilfordii, Caulis hocquartiae and leonurus all can cause different degree abnormality of urine routing, urine small proteins and the changes of renal functions. After recover of drug withdrawal, some parameter of renal functional could become normal, but the others were unrecoverable. Tripterygium wilfordii?Caulis hocquartiae and leonurus all could cause different degree change of renal morphology at high dose, but the injury region of kidney were not the same. The recovery degrees of
renal damage were not the same, after the three drugs of above-mentioned withdrawal. Renal parenchyma injury was reversable, but the renal interstitial fibrosis were almost irreparable. Conclusion: Tripterygium wilfordii?Caulis hocquartiae and leonurus could cause different character, different degree rat experimental renal damage, so it is necessary to carry out extensive deepgoing and systematic research of the mechanism of "non-aristolochic acid" renal damage of Leonurus.