Objective To explore the effect of inhibition and mechanism of long-term
nebulized inhalation of
nitroglycerin on rats with
hypoxic pulmonary hypertension. Methods 30 Wister rats were randomly divided into 3 groups: Contrast (Control) group , simple group of hypoxia (H) , group hypoxia +Neb-NTG (NH) normally. Observe mPAP, mCAP , gland lung artery three type blood vessel proportion , plasma cGMP and ET-1 , high iron hemoglobin density , right ventricle proportion and lung coefficient. Results The group NH was significance difference , compared with group H in mPAP and the type three proportion of blood vessel of lung artery, plasma cGMP and ET-1 content in the gland (P<0.001); Group H, the mPAP , type three proportion of blood vessel of lung artery , plasma cGMP and ET-1 content and right ventricle proportion compare with group Control in the gland, was significance difference(P<0.001). But among H group , NH group and control group were not significance difference (P>0.05). Conclusion (1) MPAP increases obviously because of chronic hypoxia,but long-term Neb-NTG contributes to preventing or decreasing MPAP;(2)Long-term Neb-NTG can prevent or subside lung blood vessel remodeling and right ventricle proportion increase derived from long- term hypoxia; (3) Long-term Neb-NTG has no obvious effect on MCAP,the concentration of methemoglobin, pneumonic coefficient.