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Shvoong Home>Medicine & Health>Regulatory Effect of Liver-regulating, Spleen-strengthening and Kidney-tonifying Herbs on Nerve Cent Summary

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Regulatory Effect of Liver-regulating, Spleen-strengthening and Kidney-tonifying Herbs on Nerve Cent

Article Abstract by: TsingHua    

Original Author: Journal of Guangzhou University of Traditional Chinese Medicine
To observe the regulatory effect of liver- regulating, spleen- strengthening and kidney-tonifying herbs and ginsenoside
on nerve center of rats with repeated psychological stress . Rats were randomized into 6 groups: normal group, model group, liver- regulating herb group, spleen- strengthening herb group, kidney-tonifying herb group and ginsenoside group. Tyrosine (Tyr) content in hypothalamus and hippocampus was detected by 0-phthaldialdehyde (OPA) high performance liquid chromatography (HPLC) and tyrosine hydroxylase (TH) positive cells were examined by immunohistochemical analysis . < Results > The number of TH positive cells in the arch nucleus and ventromedial nucleus of hypothalamus was significantly increased in model group (P < 0.01 as compared with normal group), liver-regulating herb group, spleen-strengthening herb group (P < 0.01 as compared with model group) and remained unchanged in kidney-tonifying herb group. Tyr content in hypothalamus was decreased in liver-regulating herb group, spleen-strengthening herb group and ginsenoside group and that in hippocampus increased in kidney-tonifying herb group and spleen-strengthening herb group (P <0.01 as compared with model group). Liver-regulating and spleen-strengthening herbs and ginsenoside can improve the stress reaction by enhancing the function of TH; liver-regulating, spleen-strengthening and kidney-tonifying herbs and ginsenoside share the same nerve-center regulatory mechanism for repeated psychological stress.
Published: June 30, 2003
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