In the medical circle of China people always show much solicitude for the discovery of new drugs from plants in recent years.It
should be noticed that in most cases the total
constituents of plants have more effectiveness than the single ones and therefore it is necessary to make an overall undersranding of the process in vivo of the said total constituents.By now quite few studies on the metabolic process of such medicines as made up of multi-constituents have been carried out systematically.The authors have studied the kinetic process in vivo of CBN(a complex injection form the active parts of herbal medicines,which are effective for stroke)in order to know and expound the characteristics of
pharmacokinetics of herbal medicines and also to explore the methodology of the study on their pharmacokinetics.They have made a test of the pharmacokinetics of puerarin and ginsenoside Rg1in CBN,which showes that after the injection of CBN into the vein(100mg /kg)puerarin quickly metabolizes in26minutes of mean retention time (MRT),while the MRT of ginsenoside Rg1takes about 3.3hours,here assuming their great difference(P<0.05).Therefore,it should be indicated that the key to the study on the pharmacokinedtics of the total constituents of herbal medicines lies in the selection of the index of test,in which it would be best to select two or three active ones with high content for test first and then everything possible should be done to test their total components.For the unknown parameters which appear in the test and the changeable laws of their changing peak and time should be fitted,i.e.,fingerprint in kine,tics.By this way it is helpful to clarify the pharmacokinetic laws of studied objects overally.