To investigate the
protective effects of
DMSA against lead induced nephrotoxicity. SD rats were randomly assigned to four groups:control group,lead treated group,high DMSA
protected group,low DMSA protected group. Rats of control group were given deionized water by gavage one hour prior to being injected with 0 9% of saline solution by i.p. The lead treated group was injected with 0 5% of lead acetate (5 mg/kg body weight) by i.p. Both high and low DMSA protected groups were given 150
mg and 100 mg DMSA/kg body weight by gavage respectively,one hour before being injected with 0 5% of lead acetate (5 mg/kg body weight). All of these treatments were done once a day,5 days/week for 12 weeks. Light microscopy of kidney and ultrastructure of proximal tuble cells were observed. Urinary lead,blood lead,renal lead,urinary protein,urinary γ glutamyl transpeptidase activity (γ GT) were determined. There was significant increase of
renal lead,urinary protein, urinary γ GT in lead treated group compared to other groups ( P <0 01). In both DMSA protected groups,urinary lead was significantly higher than that in lead treated group,but renal lead,urinary protein,urinary γ GT were significantly lower. However,we noticed that the lead induced
renal damage could not be avoided completely even though high dose of DMSA (150 mg/kg) was given.
0 5% of lead acetate (5 mg/kg body weight) injected by i.p. can cause lead induced nephropathy in rats. DMSA can partly protect against the lead nephropathy. The protective effects of high dose of DMSA (150 mg/1kg bodyweight) was superior to that of low dose DMSA (100 mg/1kg body weight).
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