Hypoglycemic Effects of Cyclocarya paliurus(Batal.)Iljinsk Ethanol Abstracts on Diabetic Mice

A hyperglycemia animal model (total of 160) was successfully developed by treating normal Kunming mice with alloxan (a kind of drug which can selective destroy the insular betacell of animal).These mice were randomly divided into five groups,they were Xiaoke Pill group,alloxan group,and three groups with different concentration  Cyclocarya paliurus (Batal.) Ilijinsk abstracts (High,Middle,Low),each group with two repeats,then these mice were orally administrated ethanol abtracts.The fasting plasma glucose,the capability of glucose tolerance and the body weight of these mice were detected during the sixweek experiment.The results showed that the plasma glucose level of those mice at high and middle concentration groups were lower than the mice of alloxan group from the second week to the fourth week (P<005),at the fourth week,the plasma glucose level of Xiaoke Pill group was also lower than alloxan group (P<005),during the last two weeks,the plasma glucose level of high and middle concentration groups were lower than the mice of alloxan group (P<001),while the plasma glucose level of Xiaoke Pill group and low concentration groups were lower than alloxan group (P<005).The body weight of the mice at low abstract concentration was low than the mice of control group (P<005).At the same time it showed that Cyclocarya paliurus(Batal.)Ilijinsk ethanol abstracts could improve the capability of glucose tolerance.