AIM: To study the influence of
Guizhi Fuling Capsule', 1, 1597821)"; href="/tags/guizhi-fuling-capsule/">Guizhi Fuling capsule on
estradiol (E 2),
progesterone (Pt), and prolactin( PRL) in the high level E 2, Pt experimental rats. METHODS: The method of ip was used to make the model of high level E 2 and Pt rats, One hundred SD female rats were radomly divided into five groups. Those were blank control group, model group,
tamoxifen group and Guizhi Fuling capsule 200, 400 mg·kg -1 groups. Each group had twenty rats. The blank control group and model group were given equal volume distilled water. Other groups were given Guizhi Fuling admixture suspension 200 or 400 mg·kg -1 , or tamoxifen 3 mg·kg -1 , by the method of ig qd, for 30 d. The influence of Guizhi Fuling capsules on plasma E 2 Pt, and PRL in experimental rats was determined by radio immunoassay. RESULTS: The plasma E 2, Pt of high level E 2, Pt experimental rats could obviously reduced in both guizhi fuling capsules 200, 400 mg·kg -1 groups. The data of E 2 were(127±52) ng·L -1 and (153±49) ng·L -1 , the data of Pt were (12±8) μg·L -1 and (13±7) μg·L -1 compared with the data of E 2 (271±103) ng·L -1 and the data of Pt (21±15) μg·L -1 of model group. It had remarkable difference, P <0.05, but the influence of Guizhi Fuling capsule on PRL in plasma was minor. CONCLUSION: The unusual risen blood concentration of the E 2 and Pt can be reduced by the Guizhi Fuling capsules in high level E 2, Pt experimental rats.
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