Objectve: To evaluate the effects of
Yi Shen Huo Xue Fang on expression of GMP 140 and cleaning out the oxygenic free
radicle on rabbits blood stasis model. Method: Thirty rabbits were divided randomly into five groups as the normal group, model group, large dose of "
Yi Shen Huo Xue Fang" group, small dose of “Yi Shen Huo Xue Fang" group and “Xue Shuan Xin Mai Ning" group. After being treated respectively ,
Granule Membrane Protein 140(Gmp 140),erythrocyte sueroxide dismutase (E SOD),erythrocyte lipid peroxide(E LPO),plasma lipid peroxide(P LPO) were checked up.Result: The GMP 140, E SOD, E LPO, P LPO in normal control were compared with those in model groups, With the difference( P <0.01),model control group was compared with large dose group and small dose group( P <0.01), with “Xue Shuan Xin Mai Ning"group( P <0.05), large dose group was compared with “Xue Shuan Xin Mai Ning" group( P <0.05),and large dose group were compared with small dose group( P >0.05).Conclusion:The model was made successfully. Large dose group, small dose group and “xue shuan xin mai ning"group can inhibit expression of GMP 140,enhence SOD activity and decrease LPO content on blood stasis rabbit model. Large dose group and small dose group have stronger effect than “xue shuan xin mai ning"group.<